| Titels | Prof. dr. |
| Initials | J.L. |
| Main position | Hoogleraar UU |
| Disciplines | Biochemistry |
| Chair | Moleculair kankeronderzoek |
| Domain | Medical, Biomedical and Health Sciences |
| Membership | Member |
| Since | 2006 |
| Member of Medical, Biomedical and Health Sciences | |
| Employed by |
University Medical Center Utrecht
Molecular Cancer Research Universiteitsweg 100 3584 CG Utrecht tel. 088 756 8989 (secr.) j.l.bos@umcutrecht.nl |
| Personal website | |
| Research/publications |
As professor in Physiological Chemistry Hans Bos aims to understand the regulation and function of Ras-like small GTPases. Ras is the paradigm of the family and mutated in 15% of all human cancers. Rap is a very close relative that functions in among others cell adhesion, integrity of cell junctions, cell migration, cell polarity and secretion.
Major breakthroughs were the discovery of the cAMP-regulated Epac protein in 1998 and the discovery of the essential role of Rap1 in integrin-mediated cell adhesion in 2000 and in E-cadherin-mediated cell junction formation in 2004. More recent highlights are the elucidation of the crystal structure of Epac. Currently the main focus is on the spatio-temporal control of the Epac-Rap1 module in cell adhesion and the downstream molecular effects.