Press release Hubrecht Institute

A deep look into the gut’s hormones

13 May 2020

Researchers from the Hubrecht Institute and Utrecht University generated an in-depth description of the hormone-producing cells in the human gut, in a large collaborative effort with other research teams. The results are presented in the scientific journal Cell on the 13 May 2020.

These cells are difficult to study, as they are very rare and unique to different species of animals. The researchers developed an extensive toolbox to study human hormone-producing cells in tiny versions of the gut grown in the lab, called organoids. These tools allowed them to uncover secrets of the human gut, for example which potential hormones can be made by the gut and how the secretion of these hormones is triggered. These findings offer potential new avenues for the treatment of diseases such as type 2 diabetes and obesity.

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Hubrecht Institute

Hubrecht Institute

The Hubrecht Institute is a research institute focusing on developmental and stem cell biology. It encompasses 24 research groups that perform fundamental and multidisciplinary research, both in healthy systems and disease models. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW)., located on the Utrecht Science Park ‘De Uithof’. Since 2008, the institute has been affiliated with the University Medical Center Utrecht, advancing the translation of research into clinical practice. The Hubrecht Institute has a partnership with the European Molecular Biology Laboratory (EMBL). 

The Hubrecht Institute is located in Utrecht (Uppsalalaan 8, 3584 CT Utrecht).

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