Massachusetts General Hospital Award in Cancer Research for Hans Clevers

19 March 2014

The ninth Massachusetts General Hospital Award in Cancer Research has been given to Prof. Hans Clevers. The MGH Award in Cancer Research, established through a bequest in memory of Grace and Nathan Schiff, has been awarded annually since 2006.

The faculty of the MGH Center for Cancer Research selects recipients based on their outstanding contributions to cancer research as well as on excellence in mentoring.

Previous recipients are Anton Berns, (2006), Joan Massague (2007), Titia de Lange (2008), Bert Vogelstein (2009), Charles Sawyers (2010), Michael Stratton (2011), Craig Thompson (2012), and James Allison (2013).

Hans_Clevers_Foto_Henk_Thomas.jpgHans Clevers' research interests include cellular and molecular mechanisms underlying tissue growth. His numerous scientific contributions to these fields, described over 400 high profile scientific publications, include the discovery of the TCF/LEF family of transcription factors and their roles as nuclear effectors of WNT signaling both in normal development and in cancer. Other important discoveries include the identification of Lgr5 as a marker of stem cells in several adult tissues, and the identification of Lgr5 and its relatives as the receptors for R-spondins, a family of potent stem cell growth factors.

The MGH Award in Cancer Research has been presented to him by Dr Daniel Haber, director MGH Cancer Center, in Boston on 14 March 2014.

The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences. Presently there are 20 research groups with a total of about 200 employees. In addition to a highly interactive and international scientific environment, excellent research facilities are available for imaging and functional genomics. Moreover, several model organisms are present, including C. elegans, zebrafish and mice. The institute is situated in Utrecht at the university centre De Uithof. The Hubrecht Institute is affiliated with the University Medical Center Utrecht and has close connections with Utrecht University, e.g. in the Graduate School Cancer Genomics and Development Biology.